A study of household economics in a Managuan neighborhood during the mid-1990s, however, described the replacement of group-based survival strategies with the emergence of "non-cooperative" households, accompanied by an ethos of mistrust among neighbors, and a refusal to share resources both within and across households [ 34].
Replacement of groups of atoms by CG beads essentially averages out the all-atom dynamics causing a smoother interaction potential and allows the use of large simulation time-steps without introducing numerical instabilities.
For 5-HT7R ligandsubstitutioniof of phenyl or 2-thiophene increases activity, as does replacement of the amide linker, especially with sulfonamide.[ 18] Here, some restrictions were applied to investigate the replacement of groups, with the knowledge that different targets might have different activity thresholds.
The structural changes included the removal of the phenyl group at C-3, the replacement of this group by a 3,4,5-trimethoxyphenyl group, the removal of the methyl group at C-5 from the lead scaffold and the replacement of this group by a phenyl substituent.
Intriguingly, replacement of phenyl group on sulfonamide with naphthyl group enhanced selectivity over PI3Kα while retaining submicromolar PI3Kβ potency.
Herein, we report the effect of replacement of nitro group(s) by other electron-withdrawing group(s) in JS-K and its homo-piperazine analogues on GSH activation and the drugs' biological activity.
The term substitution refers in general to the replacement of any group in a molecule by any other group.
Replacement of phenoxy group on position 2 by a sulfanyl group in case of compound 2 has been abolished effect on the heart rate.
Replacement of NH2 group with a methyl (7c) or SH group (8c) results in loss of activity (IC50 > 20 μM).
On the other hand, the replacement of hydroxyl groups by carbonyl groups did not significantly affect its leishmanicidal activity [ 14].
The call follows the replacement of the group's long-serving president, Gen. Bo Mya, with its secretary general, Ba Thin.
