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The optimal shape of the fully loaded PV replacement leaflet was systematically determined by minimizing the difference between the deformed shape obtained from FE simulation and an ex-vivo microCT scan of a native ovine PV leaflet.
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Multiple strategies have been used for the design of replacement leaflets, including the measurement of inter-commissural chord length (as in the accompanying paper), and multiplying annular diameter by 1.5 to obtain leaflet free-edge length.
Complete aortic valve leaflet replacement has been described for decades.
Greater application of aortic valve leaflet replacement has the potential for improving the results of aortic valve surgery.
Perhaps sufficient data are available to consider autologous pericardial leaflet replacement in highly selected younger patients with irreparable leaflets and contraindications to warfarin.
Single leaflet replacement utilizing an ovine model is an attractive approach in that candidate materials can be evaluated under valve level stresses in blood contact without the confounding effects of a particular valve design.
Bovine pericardium is used for heart valve leaflet replacement where the strength and thinness are critical properties.
Heart valve leaflet replacement with bovine pericardium is an established practice [ 1] using either adult or calf pericardium [ 2] and may be performed percutaneously [ 3].
During surgery for aortic valve replacement, all valve leaflets with exception of the valve ring were involved in the endocarditic process, with severe destruction of all valves.
In addition, the fabricated constructs opened and closed properly in an ex vivo model of porcine heart valve leaflet tissue replacement.
Only the publication of the training material in the form of posters and leaflets and the replacement of sphygmomanometers with digital equipment involved additional costs.
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CEO of Professional Science Editing for Scientists @ prosciediting.com