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An identical effect is achieved if a fluoro group is substituted with another halogen; this replacement generates compounds that are active toward 5-HT2CR and 5-HT7R.
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Sequences were aligned at the protein level using MUSCLE version 3.8.31 with default options [ 38] with minor manual corrections to eliminate spurious amino acid replacements generated by the alignment procedure.
One of the replacement polymorphisms generates a stop codon in exon 2 of Dlh in one of the lines (Figure 3).
In effect, the replacement rule generates adaptation waves traveling at an average velocity given by c = c(Δ W).
There were comparably more farms that borrowed boars from other farms for mating than those that did not, more farms sourcing replacement stock from neighbouring farms than those obtaining replacement stock generated on their own farms.
We then used permutation testing (10,000 permutations, without replacement) to generate null distributions from randomized differentially methylated CpGs (aberrant in T-iPSCs or aberrant in Y-iPSCs) across all the CpGs in the array.
The electrochemical replacement reaction generated a hollow one-dimensional (1D) structure and the high degree of alloying in the as-synthesized products.
Each set was then randomly sampled (with replacement) to generate a bootstrap replica.
Bootstrapping was done by sampling the data points for each trait/environment combination with replacement, to generate bootstrap data sets that were then analyzed in the same way as the real data.
Confidence intervals for the genetic and environmental parameters were obtained from 1,000 iteration bootstrap estimates by randomly sampling the families with replacement to generate samples with the same number of families.
Patients in the GXR trials were randomly sampled with replacement to generate 1,000 bootstrap replicates.
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