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Pfizer said in July that it was taking steps to speed the introduction of pregabalin, which is a possible replacement compound for Neurontin.
The replacement compound being tested is 2,4-dinitroanisole (DNAN).
A practical necessity to prepare for the potential loss of phosphine is identifying a replacement compound.
Their lead candidate, MRX34, a miR-34a mimic compound, will probably be the first miRNA replacement compound to reach clinical trials.
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Earlier work had established that the proposed succinate and maleate compounds exhibited higher biodegradation rates than DEHP, and pending toxicity studies, they seem to be viable replacement compounds for DEHP.
But some of the new replacement compounds may pose problems of their own.
A small molecule, DD2, previously shown to disrupt dimerization of Kaposi's sarcoma-associated herpesvirus protease (KSHV Pr) by trapping an inactive monomeric conformation and two analogues generated through carboxylate bioisosteric replacement (compounds 2 and 3) were shown to inhibit the associated proteases of all three human herpesvirus (HHV) subfamilies (α, β, and γ).
Power-point charts zip by as Ma Chen, 23, acting as the of ReLive, explains the benefits of its new bone-replacement compound.
On the basis of prior findings that phenelzine was a moderately potent, mechanism-based inactivator of LSD1, we synthesized a series of phenelzine analogues exploring hydrazine modifications, variations in alkyl chain length and rigidity, phenyl replacement, and phenyl ring substitution (compounds 9– 15, Figure 2).
The replacement in compounds 2 of the N-substituted 5-amino substituents with similar alkoxy groups usually afforded less active compounds 3.
A rather different picture emerged upon similar replacements for compound 37, which contains a CF3 moiety at the para-position of the phenyl ring.
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