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Novel therapeutic strategies to treat them include: (i) growth factor delivery to boost endogenous repair and (ii) replacement cell therapy, including replacing dopaminergic neurons to treat Parkinson's disease (PD).
Stem cell therapy is a promising potential treatment option for ALS, given stem cells' remarkable plasticity and ability to differentiate into multiple neuronal lineages [ 9]; they are consequently a valuable source for replacement cell therapy.
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Each type generates replacement cells for the particular tissue in which it is found.
Cloning is an arduous process, and using it to create tailor-made replacement cells may prove impractical.
Embryonic stem cells can turn into virtually all types of the body's cells, potentially providing replacement cells that can be transplanted into patients to cure diseases.
Also, as with many proposals for cell therapy, the replacement cells are liable to be damaged in time by whatever disease process killed the patient's cells.
It weighs the generation of new replacement cells, required for continued life, against the risk of death from cancer, which is the inevitable outcome of letting cells divide.
Medical researchers and patient advocacy groups have long hoped to use human embryonic stem cells to study diseases and supply replacement cells to treat them.
"It is one of the things that made people much more ambitious and optimistic" about using stem cells as replacement cells for humans.
The work raised the prospect that the embryonic cells might one day be used to provide insulin-producing replacement cells to treat the disease in people.
The findings also gave rise to questions about using embryonic stem cells as replacement cells for diabetics, a method that is the focus of intense interest.
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