Sentence examples for replacement approach for from inspiring English sources

In order to investigate the involvement of CS in the cross-species protection recently observed between the two rodent parasites P. berghei and P. yoelii, we adopted our gene replacement approach for the P. yoelii CS and exploited the ability to conduct reciprocal challenges.

Recently, interest has resurfaced but this time the focus is on a steroid replacement approach for what has now been termed "relative adrenal insufficiency" rather than relying on the pharmacologic effects of steroids.

Having established an in vivo gene replacement approach for Munc18-1, we next studied the role of PKC phosphorylation of Munc18-1 during presynaptic plasticity, by replacing the endogenous Munc18-1 with a PKC-insensitive mutant.

We developed a novel gene replacement approach for the calyx of Held synapse, which makes use of a floxed mouse line, combined with virus-mediated expression of three proteins: (i) Cre-recombinase; (ii) the protein of interest in mutated, or wild-type form, and (iii) the reporter gene GFP.

Despite the positive direction of LGMD-targeted gene therapies, all strategies to date focused on gene replacement approaches for recessive forms, while treatments for dominant LGMDs have been largely unexplored.

We also demonstrate that this galvanic replacement approach can be used for the formation of isolated AgTCNQ/Au microwire composites which occurs via an analogous mechanism.

Thus, while glutathione depletion was demonstrated to be a selective trigger for dopaminergic neuron degeneration, a glutathione replacement approach as a potential treatment option for Parkinson's patients must be considered with great care.

To test a MECP2 gene replacement approach in a manner more relevant for human translation, a self-complementary (sc) adeno-associated virus (AAV) vector designed to drive MeCP2 expression from a fragment of the Mecp2 promoter was injected intravenously (IV) into juvenile (4 5 weeks old) Mecp2-null mice.

Thus, EHTs may serve as material for a novel tissue replacement approach.

For targeted deletion of PbS6 the gene replacement approach was followed (Thathy and Ménard, 2002).

This paper aims to improve the effectiveness of the replacement oscillator approach for soil-structure interaction (SSI) analysis of flexible-base structures on soft soil deposits.