This provides a theoretical foundation for using the midpoint imputed data to replace the interval-censored data and can be generalized to handle a situation that censoring depends on auxiliary variables, when the main interest is in estimating the recurrence rate at the end of the trial.
Fifteen subjects (6 men and 9 women) had their first recorded CHD diagnosis at the first observed physician visit; replacing the observed interval for these subjects with the maximum interval of 10 years raised the means to 5.3 years for both men and women (p =.94).
Davis [105] extended what he calls "the ingenious method of Kato" by replacing the single interval ((alpha,zeta )) by a finite union of intervals.
They only replace the content of certain intervals with similar but slightly different content, and in that sense are more like large substitution events.
Parkinson's patients like Mr. Anderson, for example, must take medications at precise intervals to replace the brain chemical dopamine, which is diminished by the disease.
After extensive efforts to replace the disturbed, missed, or duplicated intervals found in spliced sediment sequences constructed onboard during IODP Exp.
He would be replaced at the interval, but four minutes from half-time the Dutch reeled for entirely different reasons.
The overlapping full-back, injured, had to be replaced before the interval and Scolari's plans began to go askew.
The Chilean started in that position at Goodison Park but was replaced at the interval by Giroud having struggled to make an impact.
