Finally, we also examined the effects of replacing Phe247 in the context of pre-existing a Tyr78Trp mutation.
An increasing aim in safety assessment of chemicals and drugs is to reduce, refine and replace animal testing, especially in the context of the new system for the registration, evaluation and authorisation of chemicals (REACH).
The DAS28 is suggested to be a tool to guide decision making in RA; nevertheless, it cannot always replace the clinical judgement in the context of an individual patient.
In all intoxications, % cell viability is the average from three samples, plus or minus the S.D. To test the importance of ANTXR2 residue T118, it was replaced with an alanine in the context of a human ANTXR2-EGFP fusion protein [4].
The evolution of steroid receptors can be replaced in the more general context of ligand-nuclear receptor co-evolution.
The HLE alone has a statistically indistinguishable copy number of dynein components to the hΔLE RNA, in which the localisation signal has been replaced by a heterologous sequence in the context of the h 3′UTR, yet only the former RNA is capable of unidirectional motion.
To test their involvement, each ANTXR2 residue was independently replaced by the corresponding ANTXR1 residue in the context of an ANTXR2-EGFP fusion protein [7].
This has mostly been discussed in the context of replacing native neurotransmitters with modified ones, and observing the incorporation and/or release of the latter.
Replacing leucine by histidine or alanine (in the context of identical amino acid composition, e.g., in dendrimers G1,2,3-KA and G1,2,3-KH) gave dendrimers with transfection efficiency comparable to G1,2,3-KL and 5-fold better than G2,3-KL and G3-KL.
Staff meetings can replace lectures, and lab skills are taught in the context of production runs, applying a spectrum of industry competencies, including GLP [Good Laboratory Practices] or GMP [Good Manufacturing Practices] and compliance with OSHA [Occupational Safety and Health Administration] standards".
Be sure to keep in mind that this information is not meant to replace conventional diagnoses but should be seen in the context of providing information that might identify specific predispositions.
