Clearly, the decreased PGC-1 α mRNA content observed in the present study supports the notion that repetitive stressful work tasks may rather impair cellular mitochondrial adaptations.
Consistent with the notion that repetitive elements are methylated in plants, only 2.9% of the MF sequences had a match in either of the repeat databases, while matches in the WGS set reached 8.1%.
These results join the increasing number of reports of NR and other TF binding sites in Alu or other repeat elements [ 70] and support the notion that repetitive DNA may be more than just "junk" DNA.
The notion that repetitive DNA may play a regulatory role and be involved in the evolution of gene regulation was also postulated early on, although it was not until recently that there was evidence to support those ideas [ 3- 5].
Though a long work lasting around 80 minutes, it can seem repetitive and short-breathed, any notion of overall structure occluded.
The finding, published online today in Nature, overturns the notion that this repetitive, non-coding DNA, popularly called "junk" DNA, is necessary for life.
Recent data from the treatment of patients using "pure" immunotherapeutic approaches, such as IL-2, CTLA-4/PD-1 antherapieserandes, and repetitive vaccination, would reinforce the notion that restimulation of the immune response in the patient can be remarkably effective in inducing long-term survival.
All this repetition would be merely repetitive if Alter didn't tie it to a precise notion of what's going on in nearly every passage.
In large genomes that contain abundant repetitive DNA, it encompasses also the notion of regions containing genes, the so-called gene-rich regions, surrounded by gene-poor regions composed of repeats [ 2].
The scientific management principle of breaking work down into small, repetitive tasks was based perhaps upon the notion that the worker does not think on the job.
These findings are consistent with the notion that TFBS originating from repetitive DNA elements are likely to provide functionally relevant regulatory divergence between species.
