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In experimental measurements, synaptic plasticity profiles are often measured using repetitive input pulses or waveforms and reported at steady state, i.e., the steady-state strength of the synapse is known for each stimulation frequency [23, 25, 26].
According to the STDP rule, synapses of those circuits that have a resonance frequency similar to that of the repetitive input are strengthened during stimulation.
If repetitive input reaches such circuits, the strength of their neural response depends upon the frequency at which they are stimulated, a phenomenon known as neural resonance [61].
In accordance with the frequencies of different brain waves, we set the input signals such that a sustained input has a 5-fold larger width than a transient input, and that a repetitive input comprises five pulses instead of one pulse in a one-shot input.
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Another useful function of habituation and desensitization is to tune out repetitive inputs that prove to be innocuous, thus allowing selective attention to potentially important inputs [ 173- 175].
These brain networks seem not to be disrupted per se in migraine patients but changed activity over time responding to repetitive nociceptive input.
a In most experiments both habituation and sensitization refer to measurement of effector system responses to repetitive sensory input.
Finally, spinal cord glial inhibition results in decreased potentiation of repetitive nociceptive input, thus suggesting future clinical applications in arthritic pain once glial inhibitors are available for human use.
In contrast, the same repetitive stimulation induced the LTP of excitatory inputs in strongly activated MCs (MC2) that require activity of synaptic NMDARs.
It was one of the first SPICE implementation where the model was tested under sinusoidal as well as repetitive sweeping inputs.
Furthermore, it has been shown that repetitive paired stimulation of an input into M1 such as the median nerve and then of M1 itself can change M1 cortico-spinal excitability (Stefan et al., 2000; Wolters et al., 2003).
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