Since DNKv4 motoneurons displayed substantial defects in repetitive firing, we investigated whether these defects would be translated to behaviors that involve repetitive or rhythmic movement.
All of these behavioral studies suggest that loss of Kv4 function, which is required for proper repetitive firing, results in defects in rhythmic behaviors known to depend on repetitive firing.
Tumours with chromosome instability (CIN) reveal high rates of chromosome losses and gains, whereas tumours with microsatellite instability (MSI) show genome-wide changes in repetitive sequences due to defects in the DNA mismatch repair system.
Primary CRC can be divided into two main groups, firstly tumors with chromosome instability (CIN) showing high rates of chromosome losses and gains and secondly tumors with microsatellite instability (MSI) characterized by genome-wide changes in repetitive sequences due to defects in the DNA mismatch repair system [ 20].
It minimizes the waste inherent in redundant meetings, repetitive planning, excessive documentation, quality defects, and low-value product features.
These results impose careful consideration on the use of photo-activation in studies involving blood flow regulation, as well as in studies requiring prolonged and repetitive stimulations to correct cellular defects in pathological models.
However, we cannot rule out pleiotropic effects from a lack of silencing in repetitive regions or chromosome segregation defects known to occur in ∆ dim-5 (Lewis et al. 2010).
Thus the polyploidy cells observed may represent a response to spontaneous DNA damage, replication fork collapse due to stalling in repetitive regions of the genome, defects in post-replication events such as decatenation leading to SAC activation and mitotic slippage, or a failure in cytokinesis following normal mitosis.
With ongoing repetitive loading, these tenocyte-associated focal collagen defects could predispose to the progression of overuse pathology.
All the GMPPB-CMS patients have a characteristic neuromuscular transmission defect that is detectable by repetitive nerve stimulation EMG studies on the affected group of muscles.
