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These results provide insights into the molecular structure of the repetitive backbone unit of the pilus as well as on the regions that are exposed on its surface and may be important for the development of therapeutic inhibitory molecules and for the next generation of protein vaccines.
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The latter is particularly observed for LCPs with a repetitive flexible thiophene backbone, as conformational restriction of the thiophene rings leads to a distinct optical fingerprint.
The chondroitin backbone of CS/DS-GAGs consists of repetitive disaccharide units containing D-glucuronic acid (GlcA) and N-acetyl-D-galactosamine (GalNAc) residues, or varying proportions of L-iduronic acid (IdoA) in place of GlcA [ 25, 26].
Each strand of the duplex has the repetitive form (-CH2-CHB-CO-NH- n with B as a pyrimidine base, so the backbone has a polyamide structure.
The identification of repetitive turn structures is therefore a valuable approach to predict polypharmacology or identify backbone conformations that could easily be replaced by mimetic building blocks [4].
They possess an aromatic salicylamide (Sal) or 3-amino benzoic acid (Benz) backbone, lysine (Lys), arginine (Arg) or citrulline (Cit) side chains, short length (two to four repetitive units) and various N- and C- terminal groups.
And repetitive.
A backbone".
They are the backbone.
He wants backbone.
He has no backbone".
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CEO of Professional Science Editing for Scientists @ prosciediting.com