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When purified CD4+ T cells were cultured in the presence of cell-free breast cancer cell (MCF-7) supernatants (Fig. 1A), a situation mimicking the tumor-bearing condition in which tumor-shed mediators influence the circulating CD4+ T cell repertoire, increase in the percent of dead CD4+ T cell (43.2%) in comparison to control (7.2%) was recorded.
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The evidence suggested the differences were cultural: first, the extent of the differences increased with distance, suggesting cultural diffusion was occurring, and second, the size of the orangutans' cultural repertoire increased according to the amount of social contact present within the group.
Furthermore, observation of actions performed by conspecifics results in greater MNS activation than actions performed by non-conspecifics [30], again suggesting that familiarity and the existence of a common motor repertoire increases motor resonance.
In stimulus enhancement [60], seeing a conspecific at a place or interacting with an object increases the probability of oneself subsequently interacting with those things; in response facilitation [61], seeing a conspecific executing an action that is also in one's own repertoire increases the probability of subsequently activating that action.
Second, the size of a multifunction's latent repertoire increases with the size of its genotype set.
On average, the complexity of PARP repertoire increases with the evolutionary level of the species (Table 1).
Müller et al [ 10] suggested that changing the repertoire of domain partners in a combination, along with refinement and diversification of the domain repertoire, increases functional complexity.
In a polyclonal repertoire, an increase in Ag concentration may induce a stronger CD8+ T cell response by recruiting T cells with lower affinity for Ag, thereby yielding a different interpretation of the results.
Nevertheless, we expect that the size of a multifunction's latent repertoire will increase with N, for the following reasons.
Genome size and gene repertoire can increase through gene acquisition, i.e. DNA transfer and gene duplication, and conversely, decrease by deletion [ 3, 4].
Taken together, these observations indicate that the size of a multifunction's latent repertoire will increase with the number of genes N in the circuit despite the decrease in the proportion of latent phenotypes realized by individual circuits.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com