Exact(13)
Granato A, Chen Y, Wesemann DR. Primary immunoglobulin repertoire development: time and space matter.
Deep sequencing reveals that ultralong CDR H3s contain a remarkable complexity of cysteines, suggesting that disulfide-bonded minidomains may arise during repertoire development.
Then, I will give examples on how to use them to study antibody repertoire development and its response to malaria infection in infants and profile T cell repertoire for cancer immunotherapy.
Applying these methods, we found that patients with acute GVHD demonstrated TCRBV repertoire development statistically distinct from that repertoire development in patients without GVHD.
Human syndromes of immunodeficiency and dysregulation are characterized by distinct defects in T-cell receptor repertoire development.
We recently developed statistical methods that bring increased power and flexibility to spectratype analysis and allow us to analyze TCRBV repertoire development under appropriately complex statistical models.
Similar(47)
Repertoire maturation in development of the CD8 response to Listeria involves narrowing of the TCR repertoire, associated with increased affinity [ 17].
revenues, seen as some magical elixir or at least, as Matthew O'Shea of the 19th Ward put it, "the only tool I have in my repertoire" for development.
We further used the two-syllable pairings to assess the complexity of the repertoire across development.
Perhaps most significantly, antigen receptor signaling is necessary for 'testing' and refining the antigen receptor repertoire during development.
Trainees are encouraged to exploit relationships established with members of the program faculty for both enrichment of research skill repertoires and development of long-term collaborative relationships.
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