Table of C. elegans TF repertoire motif coverage and list of TF DBDs present in C. elegans.
While HTS has enabled an unprecedented depth of coverage of immune repertoires (i.e., 10 10 sequencing reads per repertoire), there is still a vast undersampling of biological diversity, especially in human samples [ 9, 65].
In our tests, the generation of a large number of sequences allowed good coverage of the repertoire in all tissues studied, and included most of the sequences derived from conventional TU-counting.
To better understand the evolutionary pattern of these genes, we identified 16 T2R gene repertoires based on the high coverage genome sequences of vertebrates and studied the evolutionary changes in the number of T2R genes during birth-and-death evolution using the reconciled-tree method.
In order to further assess the impact of increasing the phred cutoff on repertoire composition, we determined the abundance coverage estimator (ACE), a commonly applied indicator of repertoire diversity.
We have described the results of a global proteomic analysis of the oocyst/sporozoite of Toxoplasma gondii, expanding significantly the coverage of the protein repertoire expressed by this important parasite stage.
Therefore, our methods should have provided almost complete coverage of T2R gene repertoires, although some genome sequences may still be incomplete.
Our Photo Fakeouts are legendary -- just look at the Sexy Lady Phenomenon -- and we felt it was only appropriate that as we expand our coverage, we expand our Fakeout repertoire, too.
Intuitively, stochastic diversification of the repertoire would seem advantageous, maximizing potential immune coverage without prior bias towards certain specificities.
To facilitate the coverage of the serine protease repertoire in diverse genotypes, the proteomes of the select prokaryotes representing the different taxonomic lineages in prokaryotes and occupying diverse ecological niches were chosen for the analysis.
