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And when you're actually standing there for what amounts to a true leap of faith, the repercussions of failure sink in.
A backup musician, no doubt, has the remuneration of success without the repercussions of failure.
This can be done by trying to join forces with private monetary interests to help ensure that clinical trials do not losing funding, and, more importantly, matching researchers with compounds and then supporting those research trials by removing the fears that the repercussions of failure bring.
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Indeed, the social stigma and financial repercussion of failure are so great that the founders of failed businesses become social outcasts; no one will work with them again or fund them; and all too often they end up committing suicide.
Understanding the repercussions of a failure and how this would affect them personally can often help business users to understand their role in preventing such failures.
"We failed to appreciate until too late the repercussions of our failure to socialize in the traditional Washington manner," Powell wrote.
Regulators still remember the repercussions of the failure of Lehman Brothers, and would devote all their efforts to ensuring that another large U.S. bank does not suddenly go bankrupt, said Gregory Daco, principal U.S. economist at IHS Global Insight.
Those who once proclaimed themselves pragmatists might have to face up to the failures of their own idealism and investigate plays which set out the terrible repercussions of such failures, and imagine how best we might all make a path out of this mess.
The repercussions of BHS's failure – one of the biggest corporate scandals to hit Britain in the 21st century – will continue to be felt through 2017.
As Denver Public Schools struggles to pursue a consistent reform strategy, the district is encountering a multitude of obstacles, including repercussions from its history of failure.
The repercussions of the Egyptian governments' failure of leadership will affect more than its bilateral relations with Israel.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com