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"Have you heard anything from – how can I put this – Bob Jeff Rosenshe," she repeats, "has been very kind".
Somatic instability of CAG repeats has been associated with the clinical progression of CAG repeat diseases.
Recently, the full-length mouse Xinα with fifteen Xin repeats has been shown to bundle actin filaments [9].
However, an increased number of repeats has been found in protein-coding portions of the genome, which could influence protein function and thus the phenotype [4].
Expression of transcripts with expanded CUG or CAG repeats has been shown to result in nuclear accumulation of discrete RNA foci [20], [38], [41], [42].
That reduced pH encourages the formation of triple stranded structures containing one polypurine and two polypyrimidine strands (YRY) by RY repeats has been extensively documented [15], [16].
In addition, owing to its low CGC content, YRY triplex formation by pure GAATTC repeats has been demonstrated at neutral pH [18], [19].
A recombinant lasp-1 fragment containing the LIM domain and two nebulin repeats has been shown to bind to actin molecules [25].
These events have important implications for human disease, as recombination between nonallelic low copy repeats has been demonstrated to create DNA microdeletions that are associated with complex genetic traits including mental retardation [48], autism [49], and schizophrenia [50].
The method for finding microbial repeats has been described earlier.
The transposition mechanism of these repeats has been well characterized with respect to interspersed repeats.
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CEO of Professional Science Editing for Scientists @ prosciediting.com