Exact(5)
At the N-terminus, the polyglutamine (polyQ) stretch encoded by the CAG repeats functions as potential membrane association signal.
CRISPR (clustered regularly interspaced short palindromic repeats) functions as a prokaryotic adaptive immune system that confers resistance to exogenous genetic elements such as plasmids and phages [ 75].
The C-terminal pair of tandem BRCT repeats functions as a phosphopeptide binding module, selectively binding partner proteins such as the DNA helicase BACH1/FANCJ, the DNA resectioning factor CtIP, and DNA double strand break targeting protein, Abraxas.
A recent study showed that the RFB site within the NTS1 region of the rDNA repeats functions as a cis element for Fob1-dependent recruitment of condensin to chromosomes [ 31].
In the case of the Drosophila bw D mutation, a 2-Mb insertion of heterochromatic repeats functions to physically move the normally euchromatic bw + allele to a heterochromatic environment via trans-chromosomal interactions between the two bw allelic chromosomal regions (Henikoff and Dreesen 1989).
Similar(55)
The Tn3-like transposon is flanked by 5-bp direct TTATC repeats functioning as a target site sequence.
As ANK repeats function as protein-protein interaction interfaces, VAB-19 may bind one or more conserved proteins via this domain.
Yeast Puf proteins that possess only six Puf repeats function as RNA-binding proteins that function in post-transcriptional control of gene expression [ 8, 15].
On the other hand, the pericentromeric repeats function as sites of typical heterochromatin formation and are essential for higher order structure and correct function of the centromere itself.
Additionally, the five repeats function cooperatively in LRP6, as removing any single motif from LRP6 results in significant decreases in Wnt signaling capability (MacDonald et al., 2008).
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