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We found strong interactions between OsRap2.6 and WD repeats 1 and 2 (Figure 1C).
While a construct consisting of repeats 1, 3 and 4 can serve as a seed for the entire four-repeat tau segment, the inverse does not hold.
We previously showed that repeats 1 to 3 bind to membrane anionic phospholipids, while repeats 20 to 24 are not able to do so.
The ankyrin repeat region of IκBα mediates specific interactions with NF-κB dimers, but ankyrin repeats 1, 5 and 6 display a highly dynamic character when not in complex with NF-κB.
RACK1 anchors at amino acids 39 and 40 on the 18S ribosomal RNA subunit, constantly mediated by WD repeats 1 and 2 and their associated loops (Adams et al 2011).
The WD motif located at the end of β-strand C is conserved in repeats 1 and 6.
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The third (HEAT repeats 1 8), which constitutes the Ran binding site, exhibits conformational changes throughout its length.
Most affected FRDA patients are homozygous for large expansions, usually greater than 600 repeats [1], [2].
This deletion mutant contains aa 1 462 of importin β1, corresponding to HEAT repeats 1 11, and lacks the C-terminal domain, which interacts with importin α [32].
Repeats 1 36 made up the first third, repeats 37 72 the second, and repeats 73 108 the last (Figure 1).
The β1Δ(1 462) mutant is a truncation that contains only the N-terminal domain and HEAT repeats 1 11 of the full-length importin β1 [32].
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