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Obtaining confirmation that the liver enzymes have returned to baseline before repeating treatment is recommended.
In the present phase I II trial, we combined paclitaxel with irinotecan, administering both agents on the same day, repeating treatment every 2 weeks.
We compared bees' responses to LGE from nestmates to responses in solvent control trials, repeating treatment and control five times per colony.
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The effect tended to be prolonged after repeated treatment.
Repeated treatment with U-50,488H (s.c. or i.c.v).
Repeated treatment with KYNA derivate showed no difference compared to the pretreatment with KYNA.
Between the pre-treated and repeated treatment groups, no significant difference could be noted (p = 0.969).
The repeated treatment design may prove useful for evaluating treatments to which patients cannot be blinded.
The advantages and drawbacks of the repeated treatment design used in this study are discussed.
Acute morphine administration produces hyperactivity in mice and repeated treatment induces an enhancement of this effect.
Conventional remedial methods relying on removing the condensate bank are not generally long lasting, requiring repeated treatment.
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