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Nine samples had to be excluded because of deviations from optimal performance that also remained when the complete Infinium HD Methylation protocol was repeated, suggesting insufficient DNA quality.
Throughout the large data sample, the same patterns of types and the rates of glitches were repeated, suggesting that Hawthorne effects were not prominent.
When we remapped all reads after trimming the first several bases, the same pattern was repeated, suggesting that the observation is not due to high sequencing error rates or residual adapter sequences (trimming and remapping usually solve problems with residual adapter sequences, in our experience).
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The fact that the priority setting process in Malaysia has been repeated suggests that decisions made during previous rounds can be considered and revised based on changing needs.
In the other two families, no homologous sequence flanking the breakpoints was found, but the distal breakpoints were embedded in novel low-copy repeats, suggesting the potential involvement of genome architecture in stimulating these rearrangements.
In contrast, transparent colonies were formed by inducing transcription of the repeats, suggesting that transcription of AATATT repeats was toxic to cell growth.
In length-rigid domain superfamilies, only 33% (8 out of 24) are engaged in structural repeats suggesting that internal repeats are more common in length-deviant domain superfamilies (Tables S1 and S3).
We show that hEXO1 but not hFEN1 excises G-loops formed at transcribed telomeric repeats, suggesting a mechanism by which telomeric transcription could promote recombination to maintain telomere length in the absence of telomerase.
None of these genes contain variable number tandem repeats, suggesting that the succinogens are not capable of LPS phase variation.
Similar to its human orthologue, chicken PNPLA9 contains several ankyrin repeats, suggesting the potential for protein-protein interactions.
SYM-4 is a predicted β-propeller protein with seven WD-repeats, suggesting a role in coordinating protein interactions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com