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Repeated oral administration reduced blood glucose levels at the 4th day (p < 0.001).
Repeated oral administration of ZnO NPs led to increased Zn ion content in the rat brain [38].
The distribution of the nanocomposite after single and repeated oral doses covered most of the body organs including the brain.
Furthermore, the results of a 5-day repeated oral dose toxicity study suggest that 2b has low hepatotoxicity.
The data suggest that DEHP in low repeated oral doses causes lasting effects on the hypothalamus pituitary gonadal axis.
Morbidity, mortality and gross pathology results of sub-acute toxicity study in rats after repeated oral doses were presented in this study.
The Ag level in the brain increased when mice were exposed to silver NPs through intraperitoneal injection [9], repeated oral administration [46], or intravenous injection [47].
These findings were consistently confirmed in randomised controlled trials; repeated oral administration of artemether or artesunate was safe and efficacious in the prevention of patent S. japonicum infections.
The purpose of this study was to investigate the potential toxicity of gemifloxacin by 28-day repeated oral dose in Wistar albino rats.
Another safety profile of alcoholic extract of stem-bark of B. ovalifoliolata was investigated and proved the safety with no observed adverse effect level is 500 mg/kg following repeated oral administration for 28 days in rats [118].
Twenty-eight-day repeated oral toxicity study was conducted as per the Organization for Economic Co-operation and Development (OECD) 407 guidelines [8] with slight modifications in terms of doses administered.
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