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H3K9me3 at ZNF 3' exons corresponds with the number of tandemly repeated finger domains.
In contrast, there is no relationship between the number of repeated finger domains and the likelihood of being covered by H3K36me3.
Clearly, there is a strong relationship between the number of tandemly repeated finger domains and the likelihood of being covered by H3K9me3.
To test this possibility, we classified the ZNF genes into sets depending on how many tandomly repeated finger domains were present in the gene and then plotted the percentage of each set that is covered by H3K9me3 (Figure 7).
We have shown that there is a strong relationship between the number of tandemly repeated finger domains and the likelihood of being covered by H3K9me3 (but not by H3K36me3, which correlates with the transcript level and not the number of fingers in a particular ZNF gene).
The baseline data of our study show that many industrial technicians work with their hands flexed or twisted and perform repeated finger and arm movements for more than half of the work time (table 1).
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Natural and engineered zinc finger arrays are composed of tandem repeated zinc finger modules.
Using similar methods as outlined previously, I aligned the repeated zinc finger exons from cod, zebrafish, and fugu as a representative of the more closely related percomorph species.
Thus, this analysis suggests that the repeated zinc finger exons are under strong selective pressure to maintain a 5′ CXXC domain encoding the C-terminus of a zinc finger, a central domain encoding the IZF domain, and a 3′ domain coding for the three N-terminal CxxC portion of the zinc finger.
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