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In the repeated dose schedules the median percentage weight loss was 4.4 and 12.6 in the repeated dose 0.15 mg/kg and 0.3 mg/kg groups, respectively, again indicating some toxicity at the higher repeated dose.
Repeated Dose Toxicity Database.
A database for repeated dose toxicity data has been developed.
Recommended, 0, or 1 No inhalation and/or repeated dose toxicity study was evaluated.
Repeated dose of the same nanocomposite in animal study showed slight liver and renal derangement [10].
Within the OpenTox project she is developing ontologies and Use Cases for repeated dose toxicity.
Similar(16)
To assess liver and kidney toxicity, repeated-dose toxicity (RDT) studies are conducted mainly on rodents.
The patients were randomized into a single-dose or a repeated-dose group (n = 50, each).
One hundred patients with classic TN symptoms were recruited, and randomly and equally apportioned to single- or repeated-dose group.
Since early evaluation of the potential risk to humans is not possible in humans, in vivo repeated-dose toxicity (RDT) studies are run in rodents [12 14].
However, the duration of efficacy in the single-dose group was significantly longer than that of the repeated-dose group (P = 0.032).
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