After repeated boosts to government spending, fiscal policy is also no longer working, with consumers in Japan rightly suspicious that they will eventually have to pay for the increase in borrowing through higher taxation.
This observation may explain the inability to induce 4E10/2F5-like nAbs described by several groups [28], [29], since repeated boosting may eliminate autoreactive B cells.
Most naked DNA vaccines have produced sub-optimal immune responses, even with repeated boosting, with only moderate T-cell responses when compared to live-attenuated virus or recombinant virus vaccines and very low or no humoral responses.
In this scenario, peaks of autoimmune response against critical GAS antigens may occur cyclically, due to repeated boosts, as a consequence of either recurrent infections or re-exposure to the pathogen capable of surviving within the host, causing periodic release and exacerbation of neuropsychiatric or behavioral symptoms in children.
Repeated boosts of the vaccine afford a persistent protection that may last as long as the natural murine life span.
Arthritis was induced in the right knee of Wistar rats with repeated boosting to prolong articular inflammation.
The spectrum of over 100 different types of papillomavirus pseudovirions allows for repeated boosting with different types of HPV pseudovirions without concern for preexisting immunity.
In order to minimize the circulation of activated T cells that is likely to occur with repeated boosting doses, we adopted an effective vaccination regimen of a single s.c. inoculation 600 × 10 γ-spz (Table 1).
When the vaccine is administered to a still healthy BALB-neuT mouse, repeated boosts keep it tumor free for a period of time that may well equate to its natural life span.
This delay in the HZ peak incidence is caused by cohorts born close to the time varicella vaccination was introduced experiencing less repeated boosting instances during their childhood than previously born cohorts (a mechanism that is similar to the progressive immunity model proposed in the deterministic VZV model by Guzzetta et al. (2013)).
Russian news organizations in the 1990s nevertheless relayed claims of red mercury's destructive potential at face value, and foreign news outlets occasionally repeated them, boosting the material's credibility and mystique.
