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This mouse model has a repeat size of 80 GGGGCC-repeats, without human flanking regions, which may affect repeat translation.
Our work establishes a cell culture model for C9orf72 FTLD/ALS that reproduces core findings in patients and directly links C9orf72 repeat translation to neurodegeneration.
As a consequence of motion adaptation resulting from repeated translation through the environment, the time-dependent response modulations induced by the spatial structure of the environment were increased relatively to the background activity of the cell.
Briefly, it uses a systematic search protocol, translating and rotating a guest in a putative binding pocket of a host and repeating the translations and rotations with different conformations of both guest and host to search for energetically favorable conformations, orientations, and positions of the guest relative to the host.
Briefly, it uses a systematic search protocol, translating and rotating a ligand in a putative binding pocket of a protein and repeating the translations and rotations with different conformations of both protein and ligand to search for energetically favorable conformations, orientations, and positions of the ligand relative to those of the protein.
So there is no need to repeat the translation process to develop English and Malay versions of the Quick-FLIC.
Suppression of gastrocnemius responses when toe-up rotation followed repeated backward translations indicated a change in sensorimotor set that took place immediately in the first rotation in controls while it needed several rotations to happen in PD subjects.
The original English version of the Xerostomia Inventory was translated into Dutch following the repeated back-translation procedure.
Combining the above motifs and synthons effectively produces a complex hydrogen-bonded four-component ribbon synthon described by the tertiary graph set symbol, ({text{R}}_{4}^{4} 22)·[>cf] and this synthon is repeated by translation along the [100] direction.
However, the presence of short repeats increased translation efficiency in the absence of any change in mRNA levels [59].
We repeated back-translations and made further modifications until a consensus was reached.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com