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The last repeat tends to be less variable than the internal repeats.
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Both types of repeat tend to accumulate in regions that experience low recombination such as centromeres and pericentromeres.
With each subsequent generation, the number of repeats tends to rise.
On the psychological level as well, "any sequence of mental action which has been frequently repeated, tends to perpetuate itself... ...... (PP 116).
The number of repeats tends to increase from generation to generation, accounting for the genetic anticipation characteristic of this disease (Ashizawa et al., 1992; Mahadevan et al., 1992; Salehi et al., 2007).
Anticipation is a specific event, where the number of repeats tends to increase as the disease is passed from one generation to the next, leading to increasing severity of symptoms and decreasing age of onset [ 13, 14].
So mothers who have 55 or more repeats tend to have children with hundreds.
Mutant RNAs with expanded repeats tend to aggregate predominantly within cell nuclei, forming structures called RNA foci.
(This need not involve deliberate deception; it is a common experience that stories often repeated tend to gain new features of interest in the telling).
As the gene is passed down through families, the number of repeats tend to get larger.
GAATTC repeats tend towards contraction in most tissues examined [5].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com