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Endothelium-dependent vasodilation was then assessed during combined blockade with a repeat infusion of ACh (3.0 μg/kg/min).
However, 'SIAMMS-II' will give some preliminary information about the value of retreating progressive MS with repeat infusion of autologous BM.
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The other three were given repeat infusions from different donors, and two were also cured.
The cold-induced reduction in TV was reproducible during several subsequent repeat infusions at 38 °C and 3 °C and was accompanied by decreases in bladder voiding pressure.
A treatment window of 90 days (−1 months+2 months from one-year anniversary of prior infusion) was allowed for the administration of repeat infusions.
Following a 30 min washout period (saline at 1 mL·min−1), repeat infusions of NaNO2 were administered during normoxia and hypoxia as described earlier.
Five patients have remained well with no additional treatment for their disease other than repeat infusions of pamidronate every 3-6 months.
If the pH is still <7.0 after this is infused, we recommend repeating infusion every 2 h until pH reaches >7.0 (Fig. 2).
One hindrance to PNa re-lowering is that it is usually achieved at the expense of the repeated infusion of large volume of hypotonic fluids.
Fig. 3 Effect of COX inhibitors on dural vasodilation, induced by repeated sodium nitroprusside infusions, 2 μg kg−1 min−1 over 5 min intra arterial, in intravital microscopy (a) and on the blood pressure decrease caused by the repeated infusion of sodium nitroprusside prior and post drug or control administration (b).
We hypothesised that repeated infusion of anti-TNF-α agents may induce clonal selection and that concurrent treatment with immunomodulators further predisposes patients to γδ-T cell expansion.
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