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There are a couple of unnerving literary tics – Oates has a tendency to repeat expressions of which she is especially fond ("sick-sinking" is used once too often for comfort) and she frequently breaks out into breathless italics to convey Katya's tortuous thought processes.
In fact, ordinary Congolese often repeat expressions like "the state is dying but not yet dead" or "the state is ever present but completely useless".
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In our model, HS-induced CTG repeat expression is transient.
Under physiological conditions, pericentromeric satellite repeat expression has been observed in proliferating cells and during development.
However, the impact of CUG RNA repeat expression on early developmental processes is not well understood.
SS, SW and RY conceived the idea to investigate repeat expression in sequencing data.
Noticeably, transgenes were strongly reliant on CUG repeat expression and successfully rescued by co-expression of human MBNL1.
We termed this platform the "TE-array" and profiled TE repeat expression in a panel of normal mouse tissues.
We also analyzed the recovery of IFM area in flies after a limited burst of CTG repeat expression.
There were no significant changes in mbnl2 (86.3%), celf1 (100.2%), celf2 (97.3%) or celf3 (93.5%) transcript quantity associated with CUG repeat expression.
In expanded CAG worms, the overexpression of CeMBL partially reverses the repeat-triggered pathogenesis, as does knock-down of repeat expression with siRNA (72).
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