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Marsh moves on immediately, whipping Tredwell through mid-on for a boundary and then a single to the man that Cook reflexively drops back for the repeat dose.
No clinical signs of toxicity were evident in repeat dose toxicity studies conducted in rats.
Based on these data, doses were picked for 6-day repeat dose studies for the evaluation of the side effects.
The efficacy data were used to set doses for the 6-day repeat dose side effect study in rats.
The results from the repeat dose studies were used to compare the side effect profiles of the two drugs.
This reproduction study was preceded by a 28-day repeat dose subacute toxicity study, at 0 30 100 300 mkd.
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The results of a 14-day repeat-dose toxicity study identified no toxicity with 10d.
This was a multi-center, open-label, repeat-dose safety study in adults with episodic migraine with and without aura.
The findings will help to design further studies to characterize the repeat-dose toxicity of dipfluzine hydrochloride.
Participants agreed that integrating endpoints into standard repeat-dose studies should be considered for fulfilling any immunotoxicity testing requirements, while also maximizing information and reducing animal use.
In silico and in vitro studies, together with a sub-acute repeat-dose rodent study, could be considered for this phase.
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