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To gain insights into how endogenous promoters influence HIV-1 transcription we utilized a set of inducible T cell lines and characterized whether there were correlations between expression of endogenous genes, provirus and long terminal repeat architecture.
We exploited the repeat architecture of the genome to target segmental duplication-mediated rearrangement hotspots (n = 120, median size 1.78 Mbp, range 240 kbp to 13 Mbp) and smaller hotspots flanked by repetitive sequence (n = 1,247, median size 79 kbp, range 3 96 kbp) in 2,588 autistic individuals from simplex and multiplex families and in 580 controls.
While absence of Seh1 sequence identities outside of the WD-repeat regions warrants caution, we were unable to identify any other candidate sequences with this same repeat architecture, suggesting this sequence may well be a Seh1 candidate, albeit a weak one.
Scc4, also conserved among nearly all eukaryotes, is predicted to have an extensive TPR (TetratricoPeptide Repeat) architecture.
The topology of the helices in these domains is the same as in the HEAT repeat, but the three-dimensional structure has substantially diverged from the basic repeat architecture.
Therefore, resolution of the repeat architecture of a genome can facilitate comparisons of genome size, structure and complexity, help the assembly of accurate genome sequences, and improve confidence in genome assemblies.
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Recent crystal structures of human mitochondrial termination factor MTERF1 and Bacillus cereus alkylpurine DNA glycosylase AlkD bound to DNA revealed two new superhelical tandem repeat architectures capable of wrapping around the double helix in unique ways.
The considerable repeat content and diversity in the B. schlosseri genome indicates that LRseq may have general utility for resolving repeat architectures in diverse eukaryotic genomes.
These brain areas have structural architectures compatible with multiple, parallel timing mechanisms: the regular repeating architecture of the cerebellum and the repeating loops involving the basal ganglia and cortical structures (corticostriatal loops).
Karyopherins adopt a modular HEAT-repeat architecture and are regulated by the GTPase Ran.
The ultrastructure of rice starch is studied using small-angle X-ray scattering (SAXS) and the linear correlation function is generated from SAXS data to obtain the parameters of the lamellar repeats architecture.
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