Sentence examples for repair proficiency from inspiring English sources
In this context, it should be noted that reduced expression of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and single nucleotide polymorphisms (SNPs) in Prkdc have been reported for several BALB/c strains which affected DNA repair proficiency upon ionizing radiation exposure [39-43] [39-43]
In E. coli the corresponding substitution (D1080A) produces a defective RecBD1080ACD enzyme that lacks nuclease and RecA-loading activity affecting the recombination and DNA repair proficiency of cells [23], [24].
NU7441 did not affect repair proficiency in SAOS-2 cells but significantly reduced repair proficiency in the U2OS cells.
DNA repair proficiency has also been proposed as a potential susceptibility factor for breast cancer [ 13].
Hence, cell-cycle differences are not the cause of the difference in reporter repair proficiency that we detect.
We analyzed the single and double mutant cells and tissues for their growth rate, survival, chromosomal break repair proficiency, nuclear architecture and hallmarks of premature aging.
Especially glioblastomas appear notoriously resistant to therapy, which has been attributed to DNA-repair proficiency and deregulated molecular pathways [ 1, 2].
The surgeon should hone a single technique for the vast majority of inguinal hernia repairs to maximize proficiency.
Moreover, ESCs exhibit hypersensitivity to DNA damage, efficient DNA repair mechanisms and high proficiency in antioxidant defense, which also help to maintain their genome stability (Giachino et al., 2013).
They also establish that cellular proficiency in repair of DSBs may not correlate with resistance to topoisomerase poisons, a finding with potential implications for stratification of tumors with specific DNA repair deficiencies for treatment with these compounds.
The proficiency of repairing H2O2-induced damage was strongly impaired by SNF2H knock-down, and similar impairment was observed with knock-down of both XRCC1 and SNF2H simultaneously, suggesting their role in a common repair pathway.
