Another possibility is the repair hypothesis, wherein the microchimeric cells are involved in repair mechanisms and, in response to inflammation and chronic tissue damage, these cells are actively recruited to the injured tissue and help in the repair and regeneration process [ 28].
Advances in understanding age-related changes in articular cartilage, joint homeostasis, the natural healing process after cartilage injury, and improved standards for evaluation of a joint surface made the ultimate goal of cartilage repair a possibility.
In addition to the above hypothesis that NBS1 is involved in, or regulating the "post-UNG" events during base-excision repair, the possibility that it interacts with the mismatch repair pathway should also be considered.
In addition to classical radiobiologic studies of the effects of radiation on cells, organs, humans and their environment, basic studies of DNA damage and repair, the possibility to enhance and repair, and studies of radioprotectors, emphasis was directed at the effects of radiation on large populations and at the inaccuracy of dosimetry.
Our current results cannot distinguish between these two possible repair mechanisms or eliminate the possibility that some PstI minus samples were produced without a need for the PB1 endonuclease.
Cardiothoracic surgeons' opinion was sought and they advised immediate surgical repair with a possibility of right pneumonectomy as the bronchial defect was large.
This pathway is likely linked to DNA repair; however, the possibility of other telomeric-specific protein damage/repair pathways cannot be excluded.
However, at times the site and the size of the fistula make use of local flaps for its repair a remote possibility.
We noted that MIAPaCa2 and RKO both show defective mismatch repair, suggesting a possibility that PARG deficiency may induce sensitization to MMS through defective state of mismatch repair in these human cell lines.
