Sentence examples for repair of glomerular from inspiring English sources
In the same rat model, we observed accelerated repair of glomerular endothelium accompanied by renal induction of VEGF-A signaling and increase in the Ang-1 Ang-2 rAng-1 Ang-2.
The mechanism involved in accelerated glomerulosclerosis in sVEGFR-1-treated nephritic rats might involve indirect effects on mesangial cells due to impaired repair of glomerular endothelial cells in the presence of downregulated VEGF-A.
In addition, in this model, overexpression of soluble (s VEGFR-1 accelerated the progres VEGFR-1glomerulosclerosis acceleratedithel fibrosis accomprogressionenal dysfunctiof and PTC loss [ 7], further supportinglomerulosclerosisle of VEGF-andn the mainterstitiald repair ofibrosisulaccompaniedia.
The repair of the glomerular function and the reversal of proteinuria can be due either to restructuring of existing and/or to de novo generation of podocytes.
In addition, everolimus treatment converts the reversible glomerulonephritis into chronic progressive disease in Thy1 models via the inhibition of glomerular repair [ 5].
Vascular endothelial growth factor (VEGF -A, a potent pro-angiogenic factor, is inVEGF -Ain the development of the kidney [ 4, 5], and also potentan important role in maintaining the glomerular capillary structure and in the repair process factorisg involved of glomerular endothelinl cells and peritheular capillaries (PTC) [ 14, 15, 17].
The HGF/Met system play a key role in the neoangiogenesis, exogenous administration of HGF in anti-Thy1 disease has been shown to contribute to glomerular repair though promoting proliferation of endothelial cells and regeneration of glomerular capillaries [ 92].
In the early phase of rat anti-Thy-1 nephritis following mesangiolysis, reduction in the number of glomerular endothelial cells is observed, followed by initiation of the angiogenic glomerular capillary repair process [ 102, 103].
In those who recover, complete resolution of glomerular disease occurs.
The glomerular effects consisted of a proliferative enlargement of glomerular capillaries, followed by mesangial proliferation.
A stage of glomerular hyperfiltration and hypertrophy precedes the glomerular sclerosis and the deterioration of the glomerular filtration rate [22, 23].
