Sentence examples for repair of different from inspiring English sources
Definitely, the mechanism in which Pol θ coordinates its polymerase and helicase activities to participate in repair of different types of DNA lesions remains to be determined.
Future research should aim to determine whether different complexes are involved in repair of different types of chromatin or in different phases of the cell cycle.
The PARP proteins are involved in several DNA repair pathways and thus PARP inhibition could impact on the repair of different DNA lesions.
(B) We pooled the mutational spectra – i.e., which bases were mutated and their dinucleotide (and trinucleotide) sequence contexts – that were generated in response to the repair of different lesions.
DOI: http://dx.doi.org/10.7554/eLife.02001.005 Figure 2A shows that the repair of different types of mismatches or lesions - T/G, 5-hydroxymethyl-U (hmU /G, U/G, or an abasic site opposite a G, (ab)/G – induced significantly more mutations in the reporter region than we found with the 0 MM control.
Each complex has been implicated in the repair of different substrates; the Msh2- Msh6 heteromer is involved in base:base mismatch repair as well as repair of single-base loops generated by insertion or deletion mispairing (Alani 1996; Marsischky et al. 1996) whereas Msh2- Msh3 primarily targets small loops (Habraken et al. 1996; Marsischky et al. 1996).
Differences in repair processes of different adducts may also contribute to their nonrandom distribution in DNA.
We also performed a comparative examination of repair requirements of different dI containing substrates in vitro and the results indicated that there were overlapping activities of several repair pathways in processing of dI in DNA.
Therefore the repair capacity of different cell types can be compared with each other.
Therefore, any comparison of the repair capacity of different skin cells requires that the individual cell types are isolated from the same biopsy.
These approaches resolve molecular heterogeneity that cannot be separated biochemically, including repair complexes of different composition and stoichiometry as well as molecular subpopulations with different chemical modifications.
