Previous data, predominantly involving high dose-rate fractionated irradiation with incomplete repair intervals, had indicated that the kinetics of repair of sublethal damage for acute radiation reactions in pig skin could best be defined by a biphasic repair model with half-times for repair of 0.2 and 5.4 h, partition coefficient 0.5.
It may well be that the impact of cell cycle and apoptosis was minimum after such short repair intervals and the data, thus, reflect mainly the amount of dsb induced and initial repair efficiency.
In repair studies, a correlation between cell killing and the number of dsb was only found after short repair intervals (up to 2 h) (Schwartz et al, 1988, 1990; Giaccia et al, 1992; Zaffaroni et al, 1994), but never for nonreparable dsb.
The third example is a typical engineering problem, selecting aircraft repair materials with interval data.
The results obtained are realistic and attributed to the SMP model, incorporating multi-state degradation, appropriate distribution for modeling random failures, repairs and CM interval.
After all the subnets have been attacked, they can be repaired during the dwell time ( {t}_{d_k}. ) Assume that the time interval between the repair start time and the repair end time is ( {t}_{mu_k}. ) Only if ( {t}_{mu_k} ) is less than ( {t}_{d_k} ) could the subnet be repaired in area k.
Identify the distribution and its parameter (s) for degradation/failure time, repair time, CM time interval and CM activity time at the component/subsystem level (Refer Sect. 2).
To consider several aspects including repair and maintenance duration interval in the cost model, it is necessary to evaluate their compatibility with the reliability model (Eq. 5) which deals with such features.
BER = base excision repair; CI = confidence interval; CPS-II = Cancer Prevention Study II ORR = odds ratio; XRCC1 = X-ray cross-complementing group 1.
Component testing/inspection intervals and repair times are critical parameters to define the system-state configuration, and play an important role for evaluating the probability of operational failure.
