Sentence examples for repair function and from inspiring English sources
The alkaline comet assay was employed to assess the DNA damage and repair function, and immunocytochemistry to study hMLH1 and hMSH2 expression.
The fidelity of correct nucleotide incorporation into damaged DNA is essential for Pol β repair function, and several studies have implicated conformational changes in Pol β as a determinant of this repair fidelity.
DSB repair function and resistance to IR were completely restored by IKKβ reconstitution in IKKβ-knockdown MCF-7 cells.
In addition, the suppression of DSB repair by knockdown or inhibition of IKKβ was associated with an increased sensitivity of MCF-7 cells to IR. DSB repair function and resistance to IR were completely restored in IKKβ-knockdown IKKβ-knockdownter reconstitution with an active form of IKKβ.
However, the variation among the evolved lines was not associated with differences in DNA repair function and mutability that arose during the evolution experiment [ 13, 15].
When it is cleaved by active cleaved caspase-3, PARP loses its DNA repair function and signals the cell to move into apoptosis (Cohen, 1997).
DNA mismatch repair: functions and mechanisms.
Iyer, R. R., Pluciennik, A., Burdett, V. & Modrich, P. L. DNA mismatch repair: functions and mechanisms.
Dysfunction of the BRCA1-BARD1 ubiquitin ligase can affect repair functions and lead to genomic instability.
pQY082 also harbours genes that encode several proteins with DNA repair functions and a toxin antitoxin system.
The present study has identified that the DNA repair functions and the acetylation modification of APE1 are involved in melphalan resistance of MM cells and has also shed light on future therapeutic strategies targeting specific APE1 functions by small molecule inhibitors.
