Mehrotra, P. V. et al. DNA repair Factor APLF is a histone chaperone.
Mehrotra, P.V. et al. DNA repair factor APLF is a histone chaperone.
ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks.
However, specific liver mitochondrial matrix enzymes and the mitochondrial repair factor PINK1 require ATXN2 abundance.
The tumor suppressor p53 and the DNA repair factor 53BP1 (p53 binding protein 1) regulate gene transcription and responses to genotoxic stresses.
Comparison of DNA-PKcs with another PIKK DNA repair factor, ATM, defines a common architecture for this important protein family.
Together, these findings elucidate a mechanism whereby regulation of dynamic interaction of a DNA repair factor with chromatin impacts on the efficiency of repair, and establish a link between chromatin regulation, DNA repair, and a mammalian Sir2 factor.
Here, we show that SIRT6 forms a macromolecular complex with the DNA double-strand break (DSB) repair factor DNA-PK (DNA-dependent protein kinase) and promotes DNA DSB repair.
We extensively examined the repair factor recruitment in NHF and XPG-deficient cells at different time points post UV irradiation (Figure 2E and F).
ERCC3, the single DNA repair factor included in our library that was identified by Brass et al [6] was also identified in our screen.
The proteins identified included early repair factors such as the base damage recognition glycosylases OGG1 and MYH and the late repair factor POLß, implicating the entire BER pathway.
