A friend of theirs once called it Chop Shop Heights, for all the sketchy auto repair establishments that line the streets.
We can now use these cell lines to study various aspects of chromatin dynamics during cell cycle, DNA repair and establishment of senescence.
Over the years, the image quality on some of our microfilm has deteriorated and our bound volumes are in danger of degrading beyond repair, so the establishment of an electronic archive was an urgent measure to preserve the papers' legacy.
In this study, by using the DIvA cell line, which permits the induction of multiple annotated DSBs throughout the human genome, we showed that the major DDR PI3K-like kinases ATM and DNA-PKcs have complementary and non-overlapping functions in survival, repair, and γH2AX establishment in the context of clean DSBs.
This leads to a prolonged cytokinesis-competent state characterized by continuous repair and re-establishment of the actomyosin ring.
Together, these modules promote the maintenance of a "cytokinesis-competent" state characterized by delayed progression into mitosis and the continuous repair and/or re-establishment of the acto-myosin ring.
By actively demethylating DNA, DNA repair supports the developmental establishment as well as the maintenance of DNA methylation landscapes and gene expression patterns.
Within a short time however, 5 of the watches were turned back to her, for one reason or another, so she sent them back to the Zurich watchmaker, the Wapex A.G. establishment, for repair.
We finally got to the computer store, and a woman there directed us to the computer repair part of the establishment, which was in a shed packed with pool tables.
Recently, a better understanding of the biological processes underlying tissue repair led to the establishment of new approaches in tissue engineering which comprise the combination of biodegradable scaffolds and appropriate cells together with specific environmental cues, such as growth or adhesive factors.
