This defect in ERCC1 recruitment could in principle account for the DNA repair defects of USP45-defective cells.
Tumors with certain DNA repair defects that lead to defective HR, based on synthetic lethality, are very sensitive to PARP inhibition.
The campaign also highlights Chrysler's new "lifetime" warranty for engines and transmissions, by which the company promises to repair defects as long as the vehicle is owned by its original buyer.
In its second lawsuit filed this month, the agency is suing STV Architects of Newark and a subcontractor for $3.5 million the agency says was needed to repair defects found in an elementary school in Essex County.
There is a lack of biomaterials that may be used to repair defects in bone.
Conventional surgical techniques to seal and repair defects in highly stressed elastic tissues are insufficient.
It's hard to think of another industry where customers are expected to repair defects whose fixes were developed months before.
Scaffolds for bone tissue engineering (BTE) must be mechanically competent and chemically compatible with bone tissue to repair defects.
Whole-genome sequencing identified mutational signatures, mutational burden and hyper-mutated tumors with specific DNA repair defects.
Numerous biomaterials are used in bone replacement therapy to repair defects caused by trauma, inflammation, tumor resection, or skeletal abnormalities.
Disruption of iron homeostasis always impairs the functions of these iron-requiring proteins and is genetically associated with diseases characterized by DNA repair defects in mammals.
