Exact(1)
In the present study, the effects of LDR and HDR γ-rays were investigated in relation to water up-take and seed germination efficiency, salinity stress tolerance, and antioxidant capacity, as well as dynamics of DNA damage and repair competences.
Similar(59)
The most highly expressed genes unique to strain 6475 encode proteins involved in DNA repair, competence, folate biosynthesis, or proteins of unknown function (Table 1).
DSB repair competence determines the sensitivity of cells to these agents whereby aberrations in the repair machinery leads to apoptosis.
It is important to note that DNA damage repair competence varies among individual breast tumors and closely correlates with chemosensitivity.
In the present study using human tumor specimens we show for the first time that DNA repair competence may predict breast cancer sensitivity to DNA damage-inducing chemotherapy.
However, healing of the skin lesions occurred in 8 patients only between days 14 and 21 possibly reflecting the reduced repair competence in aged patients and the continued persistence of incontinence as a precipitating factor.
We selected γH2AX, conjugated ubiquitin, BRCA1, and Rad51, proteins in the DSB repair cascade, to assess DNA repair competence because accumulated evidence demonstrates that inactivation of genes in the DSB repair pathway results in cellular sensitivity to DNA damage-inducing chemotherapy [ 16, 29, 31, 36- 38].
Factors in the sensitivity of cells to 90CE prodrugs in addition to MGMT expression (absent in 5 20% of different tumor types) and DNA cross-link repair competence are likely to include their GST expression levels (particularly those of GSTA1 type) and their net catalytic Brønsted-Lowry base content.
Briefly, we noticed links between BRCA1 mutations, cisplatin sensitivity, and DNA repair pathway competence.
We developed a SNP array-based surrogate marker of DNA repair pathway competence and found that it strongly predicted for neoadjuvant cisplatin pathological complete response in a small cohort of estrogen receptor-negative/progesterone receptor-negative/ERBB2-negative breast cancer patients [ 52].
A detailed understanding of the core DRR machinery in plants will provide researchers with an important tool for understanding what makes plants unique with respect to repair and developmental competence and for investigating how plant genome maintenance strategies differ from the mechanisms employed by animals.
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