Evolution of DNA polymerases, the key enzymes of DNA replication and repair, is central to any reconstruction of the history of cellular life.
Mr. Attia came to view the notion of repair as central to understanding multicultural relationships after two years of research at institutions including the Smithsonian Institution in Washington, the Royal Museum for Central Africa in Tervuren, Belgium, and the Musée du Quai Branly in Paris.
Constructs containing autogenous mesenchymal stem cells (MSCs) seeded in collagen gels have been used by our group to repair rabbit central patellar tendon defect injuries.
This study demonstrates the efficacy of the Chase/LV vector and its potential as a therapeutic tool to reduce scar inhibition and promote axonal growth and repair following central nervous system injury.
These patterns and their analysis support non-homologous end joining double strand break repair as central to the ageing-relatedness of DNA repair genes.
DNA damage and repair are central to aging and oncogenesis in higher eukaryotes (1) and to host resistance and antibiotic action in prokaryotes (2).
Endogeneous cell replacement is not enough to repair adult central nervous system (CNS) in patients with stroke because of the limited renewal ability and slow turnover of neural cells.
In response to various types of stress, signaling pathways converge to induce transcriptional regulation by p53 of target genes involved in cellular responses including cell cycle arrest, apoptosis, senescence, autophagy, DNA repair and central metabolism.
Wound repair of central nervous system tissues such as the RPE and neural retina is generally limited, yet evidence for RPE proliferation and wound repair has been described in young patients with CNV, after RPE rips, in animal models of laser-induced CNV, after RPE debridement, and to repopulate areas of RPE loss in vitro.
Acid adaptation requires induction of enzymes involved in DNA synthesis and repair, in central carbon metabolism, including the transcarboxylase cycle specific to propionic fermentation in propionibacteria; and in polypeptide metabolism (ClpB, ClpC) as well as the universal chaperones GroEL and GroES [ 21- 23].
