Sentence examples for repair altered from inspiring English sources

Examples of early biologic effect biomarkers include measures of cellular toxicity, chromosomal alterations, DNA, RNA and protein expression, and early non-neoplastic alterations in cell function (e.g., altered DNA repair, altered immune function).

These mechanisms include chromosomal abnormalities, oxidative stress, altered DNA repair, altered DNA methylation patterns, altered growth factors, enhanced cell proliferation, promotion/progression, gene amplification, and suppression of p53.

Although the mechanism by which As induces adverse health effects has not been clearly elucidated, multiple pathways have been suggested, including oxidative-dependent processes, inhibition of DNA repair, altered cellular proliferation, acquired apoptotic tolerance, and alterations in DNA methylation (Liu and Waalkes 2008).

"Our findings match evidence from recent clinical trials suggesting that the drugs shrink tumors more slowly over time as they repair altered mechanisms in cells, and genes return to normal function and the cells may eventually die," Baylin said.

In addition to compromising cellular migration during vascular repair, altered membrane stiffness may interfere with cellular architecture that is required for proper MSC function.

Individual susceptibility to cancer may result from host factors including differences n metabolism, DNA repair, altered expression of protooncogenes and tumor suppressor genes, and nutritional status.

Macrophages appear to be important orchestrators and effectors of tissue repair, altering their function and phenotype to meet the needs of the healing tissue [ 105].

Several studies have revealed that As mediates toxicity via inducing the production of reactive oxygen species (ROS), inhibiting DNA repair, altering DNA methylation and increasing cell apoptosis (Flora, 2011; Jomova et al., 2011).

In addition to cytokines and pathogens, NFkB and Jun proteins respond to various cell damaging factors, including free radicals and other genotoxic agents that can cause apoptosis, growth arrest, altered DNA repair or altered differentiation.

In addition to genetic alteration of DNA repair genes, altered drug transport, increased metallothionein or glutathione levels, mitochondrial alterations, and altered DNA adduct formation have been reported to contribute to drug resistance of human cancers (Graves et al, 1992; Mello et al, 1996; Kuga et al, 1997; Leighton et al, 1997; Mitra et al, 1997; Umar et al, 1997).

Neurogenesis in the adult brain, a powerful mechanism for neuronal plasticity and brain repair, is altered by aging and pathological conditions, including metabolic disorders.