Sentence examples for repair acting from inspiring English sources

Molecular chaperones are responsible for assisting in folding and conformation repair, acting on misfolded proteins to fold them into their native state.

We find cancer-associated genes, either causal or predisposing, to be transcriptional regulators involved in processes relating to the cell cycle, differentiation, and DNA repair, acting through chromatin remodeling, signaling, or transcription factor activity.

As the nuclease SpPso2 was previously identified as a key component of the ICL response in S. pombe [8], our results suggested that SpFan1 is a key component of a novel pathway or sub-pathway of ICL repair, acting in parallel with the one dependent on SpPso2.

One of the most highly connected replication fork proteins is Ctf4, which appears to function as a scaffold during DNA replication and repair, acting as a hub of protein−protein interactions (Im et al. 2009; Mimura et al. 2010; Zhu et al. 2007).

The distinctive profile of small deletions with rearrangement breakpoints showing overlapping microhomology in BRCA1 and BRCA2 mutant cancers is therefore compatible with these processes being defective and of NHEJ or other error-prone mechanisms of DSB repair acting in their place.

This difference in homogeneity between repeats located in heterochromatin and euchromatin may be explained by a lower rate of gene conversion affecting dispersed satellite-like elements or by a specific mechanism of DNA repair acting on satellite DNA (Feliciello et al. 2006).

Kanaan and Power drove around to survey the repairs, acting as driver representatives, and although Kanaan particularly did not sound confident that they would hold up, they agreed to try and continue racing.

53BP1 plays a central role in DSB repair as it contributes to NHEJ directed repair by acting as a scaffold for the accumulation of other proteins such as RIF1 35– 39 and PTIP 40 to inhibit end resection, the committing step of HR.

This work was designed to clarify details in repair pathways acting to remove DNA double-strand breaks (DSBs) induced by TMZ.

Endogenous MSCs are mobilized and contribute to tissue repair by acting as a reservoir of cells for regeneration [ 30, 31] and guarding against inflammation [ 32].

If these linear DNA molecules are not eliminated, then repair processes, acting preferentially by homologous recombination, may convert them to biochemically intact but incomplete mtDNA molecules (27).