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Kaang et al. [53] made the point that the labile state of memory is critical for the reorganization of memory triggered after memory retrieval.
Notably, the presence of sleep-related reorganization of memory representations reflected by slow potentials after early-night sleep did not correlate with the rate of subsequent insight nor was the level of reorganization more expressed in subjects who gained explicit knowledge of hidden task regularities.
We investigated the temporal and extra-temporal reorganization of memory encoding networks in refractory temporal lobe epilepsy and the neural correlates of successful subsequent memory formation.
Functional magnetic resonance imaging has demonstrated reorganization of memory encoding networks within the temporal lobe in temporal lobe epilepsy, but little is known of the extra-temporal networks in these patients.
Reorganization of memory function to the contralesional hemisphere in patients with temporal lobe epilepsy has been consistently described particularly within the medial temporal lobe (Richardson et al., 2003; Powell et al., 2007; Bonelli et al., 2010).
We investigated the reorganization of memory function in patients with temporal lobe epilepsy before and after left or right anterior temporal lobe resection and the efficiency of postoperative memory networks.
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Further analysis revealed that distinctive bursts of brain activity occurring during sleep, so-called "sleep spindles", favor the reorganization of memories stored in a region of the brain called the hippocampus, often considered to be the organ of memory.
This dissociation between post-learning, sleep-dependent, off-line reorganization of the memory trace and retention subsequent memory performance underlines the fact that we are far from understanding the spatio-temporal dynamics of systems level memory consolidation and its relation to retrieval.
Here, focusing on the role of sleep-related memory processes, we tested whether false memories can be created (a) as enduring memory representations due to a consolidation-associated reorganization of new memory representations during post-learning sleep and/or (b) as an acute retrieval-related phenomenon induced by sleep deprivation at memory testing.
Whereas 'retroactive interference' due to new incoming information is most likely dependent on encoding and memory updating processes, sleep might affect the formation of false memories through semantic generalization by active reorganization of the memory trace in the post-learning sleep period.
We used a visuospatial working memory functional MRI paradigm to investigate: (i) postoperative recovery and reorganization of working memory networks in patients with left and right TLE before and 3 and 12 months after ATLR compared with healthy control subjects; and (ii) the efficiency of these postoperative changes in working memory networks.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com