The correlation of these mutations in G3 sub-families suggests that a similar reorganization of the interaction network stabilizing the inactive state might be shared by G3 receptors.
Thus, the differential fat tissue expansion observed in C57Bl/6 mice under HFD was associated with up-regulation of a large group of genes required for reorganization of the interaction between the adipocyte cytostructure and its tissue environment.
Application of Trac-looping to human CD4+ T cells revealed substantial reorganization of enhancer promoter interactions associated with changes in gene expression after T cell receptor stimulation.
Earlier reports have shown that reorganization of intramolecular interactions among the main intracellular loops of Cav2 channels critically influence channel inactivation.
Indeed, the NBD1 domain of ΔF508-CFTR exhibits broader conformational freedom than WT-NBD1, which is probably induced by reorganization of the interactions network between residues.
Following reorganization of snRNP/intron interactions, the branch point A nucleotide carries out a 2′OH nucleophilic attack on the 5′SS, resulting in cleavage of the intron from the upstream exon.
Peric-Hupkes, D. et al. Molecular maps of the reorganization of genome nuclear lamina interactions during differentiation.
Here, our results from a variety of computational, fluorescence and molecular biology approaches indicate a reorganization of protein-carbohydrate interactions when the glycoprotein is stressed.
Our proposed regulatory model does not involve reorganization of the D1-D2 domainteractionion but requires flexibility in the linker between the transmembrane domain and the first D1 phosphatase domain.
Peric-Hupkes, D. et al. Molecular maps of the reorganization of genome-nuclear lamina interactions during differentiation.
