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The phenotypic switch from epithelial to mesenchymal is characterized by profound morphologic changes, such as the loss of apico-basal polarity and reorganization in the distribution of organelles and cytoskeleton components that are related to a mesenchymal switch in the expression of cell lineage specific genes and levels of proteins.
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This in turn should lead to reorganization of the distribution of place fields (i.e. the generation of a new "map" or memory).
This membrane reorganization can alter the distribution of lipids and lipid rafts in the membrane.
By histochemical and immunofluorescence methods, we found a reorganization of muscle fibers and extracellular matrix, with changes in the distribution of glycoproteins, proteoglycans, and collagen.
In addition, the distribution of abundances is also affected by habitat destruction, resulting in significant reorganization of relative abundance (Fig. 2a), but we will focus here on species loss.
To identify transcription factors that may be involved in this global reorganization of chromatin, we next explored the distribution of consensus binding motifs for differentially expressed HSPC-TFs across the most variable H3K9ac peak-regions (see Material and Methods).
Importantly, we also investigated the effect of induced heterochromatin reorganization in the absence of cellular differentiation.
However, this is not the only reorganization in the lipid content of the mutants.
For example, extensive changes in the distribution and morphology of the ER have been followed during a 15-minute period from the onset of reorganization beneath a Phytophthora sojae hypha growing across the outer epidermal cell wall [ 20].
Stress-induced reorganization and spatial distribution of many key metabolites in plants require efficient transport machinery.
Recent studies revealed profound reorganization of synthesis and distribution of major structural lipids in infected cells.
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