B1 cells might constitute a separate self-renewing lineage that derives from the fetal liver, is located predominantly in the peritoneal cavity and does not seem to depend on BAFF for survival [ 42, 43] (Fig. 2).
The plasticity of stem cells allows them, when activated, to renew several lineages of differentiated cells during homeostasis.
The advent of reprogramming and its impact on stem cell biology has renewed interest in lineage restriction in mammalian embryos, the source of embryonic (ES), epiblast (EpiSC), trophoblast (TS), and extraembryonic endoderm (XEN) stem cell lineages.
Yamamoto, R. et al. Clonal analysis unveils self-renewing lineage-restricted progenitors generated directly from hematopoietic stem cells.
Yamamoto R, Morita Y, Ooehara J, Hamanaka S, Onodera M, Rudolph KL et al. Clonal analysis unveils self-renewing lineage-restricted progenitors generated directly from hematopoietic stem cells.
Differentiation of embryonic stem cells (ESCs) into specific cell types with minimal risk of teratoma formation could be efficiently directed by first reducing the differentiation potential of ESCs through the generation of clonal, self-renewing lineage-restricted stem cell lines.
Bulge stem cells have been proposed to move down the hair follicle to renew hair follicle lineages, whereas they move upward to replenish the epidermis under stressed conditions.
Stem cells are cells specialized cell, capable of renewing themselves through cell division and can differentiate into multi-lineage cells.
First, there may be a renewing precursor cell in the liver that generates the population, as suggested by experiments in the Peng paper where liver lineage− cells could give rise to CD49a+DX5- trNK cells in the liver.
Stages follow as mutations accumulate sequentially in those cell lineages, just as cancer may arise by mutations accumulating in the stem cell lineages that renew epithelial tissues.
When you're renewing, truly renew.
