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Reduction of the level of these factors is consistent with loss of renewal capacity.
They proposed three distinct compartments - the stem cell fraction with a theoretical unlimited self-renewal capacity, the progenitor pool which displays limited renewal capacity and finally the differentiated compartment, with cells having no proliferative ability and a finite life span.
Moreover, CD117 PSCs showed long-term self renewal capacity after serial isolation and transplantation in vivo.
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Knockdown of ciliary proteins significantly reduced self-renewal capacity.
These cells are highly expandable, and have self-renewal capacity, paracrine properties, and multi-differentiation potential.
Open image in new window Figure 2 Gadeletionletion aggravates the defect of self-renewal capacity of ATM−/−HSCs.
They functionally showed that the ectopic expression of SOX2 in vitro caused enhanced self-renewal capacity in melanoma cells.
In prostate cancer stem cells, the activation of EGFR signaling increased SOX2 expression and the self-renewal capacity [59].
However, treated tumorsphere cells retain the self-renewal capacity.
These cells show self-renewal capacity and multipotency.
In addition, the self-renewal capacity of hNSCs is more limited than hESCs [17].
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