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To determine whether AspM-CreERT2 long term descendants that are detected in the adult SVZ, display features of neural progenitor cells, we tested their multipotency and self renewal capability by using standard clonal colony formation assay [44], [45].
From an ecological perspective, natural mortality plays a fundamental role in the year-to-year dynamics of a population and its long-term renewal capability.
Reversing cancer stemness, together with conventional chemotherapy, could provide an ideal approach for prevent cancer recurrence and metastasis by eradicating both the bulk tumor cells and the cancer stem cells with self renewal capability.
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This self-renewal capability is dependent on intestinal stem cells (ISCs)—the crypt base columnar (CBC) cells marked with the leucine-rich repeat-containing GPCR5 (Lgr5) (Fig. 2).
In addition to long-term self-renewal capability, MSCs possess versatile differentiation potential ranging from mesenchyme-related multipotency to neuroectodermal and endodermal competency.
In addition, TAZ endows self-renewal capability of breast cancer cells to sustain the cancer stem cells population (Cordenonsi et al., 2011).
Reprogrammed iPSCs from Terc destabilized DC patients could overcome the critical limitation in Terc levels to restore telomere maintenance and acquire self-renewal capability (Agarwal et al., 2010).
As an alternative cell source to BMSCs, adipose-derived stem cells (ASCs) have been investigated for bone repair because of their osteogenic potential and self-renewal capability.
Adipose tissue derived stem cells (ASCs) based therapies for the repair and regeneration of various tissues have been widely investigated recently because of their multilineage potential and self-renewal capability.
However, in vitro expanding of TSCs on regular plastic cell culture dishes only yields a limited number of TSCs before they lose the stemness, i.e., the self-renewal capability and multipotency.
Previously, Mbd3−/− cells were shown to retain self-renewal capability upon withdraw of LIF and also to show defective differentiation potential [32].
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